Denise Marie (Wayne) Duplechian, 66, of Hopewell Township, formerly of Hermitage, Pennsylvania passed away after a battle with cancer on March 21st, 2025.
She was born in Sharon, Pennsylvania on January 23, 1959. She was preceded in death by her mother, Dolores (Messere) Wayne, her grandparents, Louis and Antoinetta Messere, and her beloved dog, Blue. She is survived by her father, David Wayne, a loving sister, Brenda Van Wyhe, a cherished niece, Mackenzie Van Wyhe, her aunt and uncle, Donna and Edward John Gallagher, cousins Kathy Walko and Ed Gallagher and his wife, Carol. Denise was a graduate of Hickory High School. She worked previously in the Shenango Valley at the A&W Restaurant and D’Onofrio’s Food Center. In the Pittsburgh area, she was a former manager at Sam’s Club for many years and most recently worked at Mortgage Connect.

She was an avid Steelers fan who enjoyed traveling, going to concerts and the casino and spending time with neighbors and friends on her deck. Denise made lifelong friends wherever she went and was a favorite of many.

In accordance with Denise’s request, there were no services, but there will be a celebration of her life to be scheduled in the near future. Arrangements have been entrusted to the Anthony Mastrofrancesco Funeral Home, Inc., 2026 McMinn Street, Aliquippa.